CompletedNot Applicable

Retaining Cognition While Avoiding Late-Life Depression

United States94 participantsStarted 2011-07

Plain-language summary

This study will adapt Problem Solving Therapy (PST) for individuals with mild cognitive impairment (MCI) as an intervention for preventing major depression (DEP). PST will be modified so as to be provided to both MCI probands as well as their support person. The primary aim is to examine the effectiveness of PST in individuals with MCI and the support person, at preventing DEP over 12 mos. in MCI probands. We also will examine the effect of exercise on preventing depression.

Who can participate

Age range60 Years

SexALL

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Inclusion criteria

✓. =\> age 60
✓. Modified Mini Mental State (3MS) =\> 80
✓. MCI diagnosis
✓. Adequate physical and sensory function to undergo NP assessment
✓. PHQ-9 score 1-9, with at least one of the cardinal symptoms of depression (low mood or anhedonia) endorsed.

Exclusion criteria

✕. Major Depressive Episode or anxiety disorder within the past 1 year
✕. Currently taking an anti-depressant
✕. History of Bipolar Disorder or Schizophrenia
✕. Drug or alcohol use disorder within 12 months
✕. Currently taking anti-anxiety med \>4x/week for the past 4 weeks
✕. =\> age 18
✕. Modified Mini Mental State (3MS) =\> 80
✕. Normal Cognitive Function

What they're measuring

Incidence of depression or anxiety disorders

Timeframe: 15 months

Trial details

NCT IDNCT01886586

SponsorUniversity of Pittsburgh

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-06

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