Patients undergoing orthotopic liver transplant will experience some degree of clinical and/or biochemical hepatic dysfunction. This early injury is known as primary graft dysfunction and varies from minor abnormalities to primary nonfunction. Prostaglandin-class drugs, including prostacyclin and its analogs, could represent an important advance toward the goal of reducing transplant related morbidity, mortality and associated costs by providing these benefits.
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Duration of the initial hospitalization (days) following transplantation
Timeframe: up to 180 days
Area under the curve (AUC) of serum aspartate transaminase (AST) levels.
Timeframe: 7 days