CompletedPhase 2

Proof of Concept of an Anaplerotic Study Using Brain Phosphorus Magnetic Resonance Spectroscopy in Huntington Disease

France10 participantsStarted 2013-05

Plain-language summary

The purpose of this project is to study the efficacy of an anaplerotic treatment on brain energy profile evolution at an early stage of the Huntington disease.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * 5 \< UHDRS \< 50 * Age \> 18 years * Ability to undergo MR scanning * Covered by french social security Exclusion Criteria: * Evidence of psychiatric disorder * Attendant neurological disorder * Contraindications to MRI (claustrophobia, metallic or material implants) * Severe head injury * Unable to understand the protocol * Pregnancy * Failure to give informed consent * Subjects with exclusion criteria required by french law (e.g. subjects who require a legally authorized representative to obtain consent) * Unwillingness to be informed in case of abnormal MRI

What they're measuring

Ratio of Inorganic Phosphate (Pi) Over Phosphocreatine (PCr): Pi/PCr

Timeframe: visit 1 (baseline), visit 2 (after 1 month of treatment)

Trial details

NCT IDNCT01882062

SponsorInstitut National de la Santé Et de la Recherche Médicale, France

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2013-07

Results submitted2015-04-30

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