CompletedPhase 4

Postoperative Neuroinflammation and Cognitive Dysfunction After Abdominal Surgery

8 participantsStarted 2013-06

Plain-language summary

The main purpose of this study is to assess the induction of neuroinflammation in brain regions of interest for learning and memory in adult patients undergoing urological surgery under general anesthesia

Who can participate

Age range60 Years – 75 Years

SexALL

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Inclusion criteria

✓. Patients 60-75 years of age. American Society for Anesthesiologist' criteria (ASA) physical status I-III
✓. Lower abdominal surgery (hysterectomy/prostatectomy) under general anaesthesia
✓. Obtained consent within 3 months before execution of the study.

Exclusion criteria

✕. Patient's refusal to participate in the trial
✕. Ongoing smoking, snuff or other nicotine compound treatment
✕. Disabling neuropsychiatrical disorder (a Mini mental State Examination (MMSE) score ≤ 24, diagnosis of dementia, Mb Alzheimer, Mb Parkinson, schizophrenia, or mental depression) or other signs of significant cognitive decline.
✕. History of stroke with neurological sequelae
✕. Surgical procedure scheduled for regional anaesthesia.
✕. Severe cardia and/or renal and/or hepatic impairment.
✕. Coagulopathy.
✕. Terminal phase of a chronic disease.

What they're measuring

Binding of the PET probe [11C]PBR28

Timeframe: Preoperatively, once at postoperative day 2-5 and after 3 month

Trial details

NCT IDNCT01881646

SponsorKarolinska University Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-02

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