Bioactive Glass (Sol-gel) for Alveolar Bone Regeneration After Surgical Extraction

Inclusion Criteria: * Patients must have good oral hygiene (confirmed by OHI-S) * Patients who had voluntarily agreed on signing an informed consent including the duration and all the steps of the trial * Patients who are indicated for the administration of the type of local anesthesia used in the trial * Patients who need myofunctional therapy including premolar extraction as part of two stage treatment (class II division I) * Patients indicated for premolar extraction as a normal step in the treatment plan not intentionally for the experiment. * Patients who had undergone x- rays on the premolar teeth showing root form and the shape of the socket prior to extraction Exclusion Criteria: * Patients with history of bleeding disorders which will hinder the normal healing process of the needed sockets for the trial * Patients with history of allergy to foreign bodies , i.e. susceptible to reactions from Bioglass * Patients with history of hypertension and diabetes , rendering them not indicated for administration of the recommended type of local anesthesia nor even for extraction * Patients having HCV , HBV , HIV or other infectious diseases to make sure of the safety of the research team and the participants from probable infection . * Mentally retarded patients who are not able to understand the steps of the trial Patients with systemic diseases or febrile illness making them unable to follow the appointments arranged * Patients who simultaneously participate in other resea…