Quantification of Immune Cells in Women Using Contraception (CHIC II)

Inclusion criteria

• ✓. Age 18 through 34 years (inclusive) at screening
• ✓. Non-pregnant women in general good health as determined by the site clinician
• ✓. Premenopausal with history of regular menstrual cycles (regular cycles defined as occurring every 21-35 days when not using hormones and with a variation of typical cycle length of no more than 5 days)
• ✓. Women enrolling into the control group only: Regular and consistent condom use, prior surgical sterilization by participant or sexual partner, or heterosexually abstinent for entire study participation
• ✓. Able and willing to provide written informed consent to be screened for and to take part in the study. Including willingness to undergo all study-related assessments and follow all study-related procedures
• ✓. Able and willing to provide adequate locator information
• ✓. HIV-uninfected based on testing performed by study staff at screening (per HIV testing algorithm in Appendices I)
• ✓. At screening and enrollment, agrees not to participate in other research studies involving drugs, medical devices, or vaginal products while enrolled in this trial

Exclusion criteria