Dapsone Prurigo Study

Inclusion Criteria: * • Active prurigo nodularis or lichen simplex chronicus - diagnosed by clinical exam * For lichen simplex chronicus patients: Severity of maximum pruritus in the last 24 hrs at least 5 out of 10 on a visual analogue scale. * For prurigo nodularis patients: Excoriations or signs of other scratch related activity at presentation to demonstrate active disease * Symmetrical disease/excoriations allowing for a side-by-side comparison (eg, bilateral lichen simplex chronicus or bilateral prurigo nodularis) - genitals, face, axillae or neck cannot be used for side-to-side comparison * Willing to refrain from use of all other topical medications in the treatment areas. * Able and willing to provide written informed consent * Willing and able to understand and comply with the requirements of the study, apply the treatment combinations as instructs, attend required study visits, comply with study prohibitions and able to complete the study. * Male or non-preganant, non-lactating female between 18 and 75 years of age, inclusive * For females of child-bearing potential, willing to use adequate birth control during the study conduct Exclusion Criteria: * • History of non-compliance with follow up visits * Should we exclude failure to certain treatments as an exclusion criterion? Patients who failed oral dapsone should be excluded * Presence of any skin condition on the treatment areas that would interfere with the diagnosis or assessment of act…