CompletedNot Applicable

Screening To Obviate Preterm Birth

United States589 participantsStarted 2013-01

Plain-language summary

Our objective is to investigate the predictive value of a panel of biomarkers associated with two biologically plausible pathways of preterm birth: membrane breakdown and cervical remodeling. The investigators will obtain cervical length, cervicovaginal fetal fibronectin, and a panel of novel cervicovaginal biomarkers associated with cervical remodeling in a prospective cohort of symptomatic women with a singleton pregnancy at high risk for preterm birth in an effort to better risk stratify this cohort.

Who can participate

SexFEMALE

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Inclusion Criteria: * Singleton pregnancy between 22- 33 6/7 weeks of gestational age. * Must be experiencing one ore more of the following symptoms including but not limited to preterm contractions, abdominal cramping, back pain, vaginal pressure, or light vaginal bleeding. Exclusion Criteria: * Women with a multi-fetal pregnancy * Intra uterine fetal demise * Preterm premature rupture of membranes * Overt chorioamnionitis

What they're measuring

Preterm birth

Timeframe: Enrollment through delivery

Trial details

NCT IDNCT01868308

SponsorUniversity of Pennsylvania

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2015-02

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