Role of ASICs in Human Inflammatory Pain (NCT01867840) | Clinical Trial Compass
CompletedNot Applicable
Role of ASICs in Human Inflammatory Pain
France20 participantsStarted 2018-01-01
Plain-language summary
In recent years, ion channels have emerged as new therapeutic targets for pain. Among these channels, ASICs (Acid Sensing Ion Channels) are of particular interest because they are directly activated by extracellular acidity, which is a major cause of pain. Indeed, many painful conditions such as ischemia, inflammation, tumor development or tissue incision are accompanied by tissue acidification. ASIC are excitatory ion channels that are expressed in neurons, including nociceptive sensory neurons. In humans, the use of amiloride, a nonspecific inhibitor of ASICs, has demonstrated their role in the perception of pain induced by subcutaneous injections of acidic solutions. ASICs thus appear as new candidates capable of mediating pain in humans. A growing number of data suggests that, in addition to protons, ASICs may also be activated by one or more endogenous compounds produced during inflammation. The purpose of this research project is to identify these compounds by testing the effects of human inflammatory exudates on ASICs activity. The discovery of such compounds would definitely validate ASICs as novel therapeutic targets for pain treatment in humans
Who can participate
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* septic arthritis
* gonarthrosis in push-inflammatory
* microcrystalline arthropathies
* chronic inflammatory rheumatism
Exclusion Criteria:
* refusal to participate in the protocol
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This trial studied acid-sensing ion channels in joint fluid from people with conditions like osteoarthritis, rheumatoid arthritis, and gout — could you explain what that means for understanding my specific type of arthritis and whether the findings are relevant to my situation?
2Since this trial is listed as completed and was focused on measuring electrical activity in ion channels rather than testing a treatment, is there published data from it that might influence how you approach my pain management?
3This study collected synovial fluid samples to examine these ion channels — is that kind of joint fluid analysis something that would be useful or appropriate in my own care, and what would it tell us?
4Because this was a research study focused on understanding the biology of inflammatory pain rather than testing a drug or therapy, what practical next steps or treatment options does it point toward that we should be discussing for my condition?
5Are there follow-up trials that came out of this research that are now testing actual treatments targeting these acid-sensing ion channels, and would any of those be worth exploring for my type of arthritis?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
activation or miodulation to Electrical potential of ionic channel in the synovial fluid