The Effect of Aspirin Desensitization on Patients With Aspirin-exacerbated Respiratory Diseases

Inclusion Criteria: * Patients with clinical diagnose of aspirin-exacerbated respiratory disease * History of physician diagnosed asthma. * History of physiacian diagnosed chronic rhinosinositis with nasal polyps. * Positive reaction to aspirin challenge test. * Stable asthma (post-bronchodilator FEV1 of 70% or better, no increase in baseline dose of oral glucocorticoids for at least 3 months, and no history of hospitalization or emergency room visits for asthma for at least the prior 6 months). Exclusion Criteria: * Being smoker * pregnancy * Current breastfeeding * History of bleeding diathesis * History of transient ischemic attack or stroke, or diabetes. * History of abnormal hepatic function * Uncontrolled hypertension or use of beta blocker medication. * History of gastrointestinal ulcers or gastrointestinal bleeding.