CompletedPhase 1/2

Effects of Octanoic Acid for Treatment of Essential Voice Tremor

United States17 participantsStarted 2013-07

Plain-language summary

Essential voice tremor is a neurological condition that produces a regular, shaking quality in the voice. One form of drug treatment that produces some improvement in tremor of the hands is octanoic acid, which is a food additive that is similar to alcohol. Research suggests that octanoic acid may reduce tremor in the hands/arms with few side effects and no intoxication effects. This study will determine whether octanoic acid may be useful for reducing tremor when it affects the voice. Researchers are hypothesizing that octanoic acid will reduce the effects of tremor on the voice.

Who can participate

Age range21 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Participants have a diagnosis of essential voice tremor and show signs of tremor during the endoscopy examination (when pictures of the voice box are obtained)during screening appointment * Participants show measurable voice tremor from recordings of the voice during screening appointment Exclusion Criteria: * Participants have a diagnosis or show signs of Parkinson's Disease or another non-essential tremor movement disorder * Participants have a diagnosis or show signs of spasmodic dysphonia (a different neurological voice disorder) * Participants have a diagnosis of a severe, non-stable medical condition, such as kidney or liver failure, severe heart disease, severe lung disease, severe metabolic disease, uncontrolled hyperthyroidism, or other life-threatening disease such as active cancer * Participants have a diagnosis of diabetes mellitus * Participants are unable to suspend/stop a medication that they are currently taking for tremor or voice disorder for 12 weeks to complete this study * Participants have a dependence on alcohol or allergy to alcohol * Participants are pregnant or lactating * Participants have an allergy to soy * Participants have Irritable Bowel Syndrome

What they're measuring

Magnitude of Acoustic Amplitude Tremor and Magnitude of Acoustic Frequency Tremor

Timeframe: Measured at baseline visits (1 & 2) and after 3 weeks of placebo or octanoic acid on post-test visits (1 & 2)

Trial details

NCT IDNCT01864525

SponsorSyracuse University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-12-22

Results submitted2018-05-19