CompletedPhase 2

Hepatic Arterial Infusion (HAI) With Floxuridine (FUDR) and Dexamethasone (Dex) Combined With Systemic Gemcitabine and Oxaliplatin in Patients With Unresectable Intrahepatic Cholangiocarcinoma (ICC)

United States55 participantsStarted 2013-05

Plain-language summary

The purpose of this study is to use both, liver pump treatment and systemic chemotherapy, to assess the effects this type of treatment has on the patient and the tumor. Liver pump treatment uses a metal pump that is surgically placed in the abdomen and gives chemotherapy directly to the liver. Systemic chemotherapy gives chemotherapy through a vein \[intravenously (IV)\] and treats the whole body. This type of treatment has been done before and had shown that people with both pump and systemic chemotherapy had improved results. The investigators hope that this combination of treatments improves the response to chemotherapy and reduces the spread of the disease. Another purpose of this study is to learn the clinical importance of a specific type of MRI scan. The investigators would like to see if this type of MRI will help predict the response to the treatment and see if they could help the physician with their treatment plan. These scans will be done at specific time points. The last purpose of this study is to learn more about how the tumor interacts with the chemotherapy. This will be done through a biopsy taken during surgery and blood draws at specific time points. Permission from patients entering the study will be obtained to take normal and tumor liver biopsies at the time of surgery. These samples are voluntary and optional.

Who can participate

Age range21 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥ 21 years * Histologically confirmed intrahepatic cholangiocarcinoma (also variously reported as peripheral cholangiocarcinoma, cholangiolar carcinoma or cholangiocellular carcinoma) (ICC). Confirmation of the diagnosis at MSKCC or at the enrolling institution must be obtained prior to initiation of protocol therapy. * Clinical or radiographic evidence of metastatic disease to regional lymph nodes will be allowed, provided it is amenable to resection. * Radiographically measurable disease. Measurable disease is defined as disease that can be assessed with 2-dimensional measurements on a cross-sectional imaging. Minimum lesion size is 2cm in greatest diameter as per RECIST criteria. * Disease must be considered unresectable at the time of preoperative evaluation. * Presence of less than 70% liver involvement by cancer. * Patients may have failed ablative therapy * Patient previously treated with systemic chemotherapy will be eligible * KPS ≥ 60% and be considered candidates for general anesthesia, abdominal exploration and hepatic artery pump placement * Patients with chronic hepatitis and/or cirrhosis are eligible, but must be Child-Pugh class A * Patients must be able to read, understand and sign informed consent * WBC ≥ 2,000 cells/mm3 * Platelet count ≥ 75,000/mm3 * Creatinine ≤ 1.8 mg/dl * Total bilirubin \< 1.5 mg/dl Exclusion Criteria: * Presence of distant metastatic disease. Patients will undergo radiographic evaluation to exclude the pos…

What they're measuring

progression free survival for Cohort 1

Timeframe: 6 months

progression free survival for Cohort 2

Timeframe: 3 months

response for Cohort 3

Timeframe: 6 months

Trial details

NCT IDNCT01862315

SponsorMemorial Sloan Kettering Cancer Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2025-03-18