Superficial Siderosis in Patients With Suspected Cerebral Amyloid Angiopathy

Inclusion Criteria (study group): * Fulfillment of the modified Boston criteria for CAA-related hemorrhage with evidence of supratentorial superficial siderosis on MRI * MR-/CT-/digital subtraction (DS) -angiography without evidence of cerebral aneurysm, arterio-venous malformation (AVM) , AV-fistula or other pathology of relevance (e.g. tumor, hemorrhagic infarction) * A maximum of two lobar or cerebellar intracranial hemorrhages (ICH) (old or acute) * Written informed consent by patient or guardian prior to study participation * Willingness to participate in follow-up Inclusion Criteria (control group): * Fulfillment of the classic Boston criteria for CAA-related hemorrhage * Absence of superficial siderosis on MRI * A maximum of two lobar or cerebellar ICHs (old or acute) * MR-/CT-/DS -angiography without evidence of cerebral aneurysm, AVM, AV-fistula or other pathology of relevance (e.g. tumor, hemorrhagic infarction) * Written informed consent by patient or guardian prior to study participation * Willingness to participate in follow-up Exclusion Criteria (both groups): * Severe medical condition with expected life expectancy \<3 years * More than two lobar or cerebellar ICH (old or acute) * any intracerebral hemorrhage in the deep grey matter (basal ganglia or thalami) or in the brain stem * History of head trauma resulting in loss of consciousness or radiologically visible traumatic brain injury (contusions, diffuse axonal damage) in the last 5 years prior to inclu…