Pilot Study Characterizing Adipose Tissue Leukocytes by Flow Cytometry/Microscopy in Lean, Obese and Psoriatic Subjects

Inclusion Criteria: * Psoriatic lean cohort (BMI between 18-24.9 Kg/m2): moderate to severe plaque-type, at least 5% of BSA * Psoriatic obese cohort (BMI between 30-40 Kg/m2): moderate to severe plaque-type, at least 5% of BSA * Lean/non-psoriatic cohort: BMI between 18-24.9 Kg/m2 * Overweight/obese non-psoriatic cohort: BMI between 30-40 Kg/m2 * Subjects must be 18-65 years of age Exclusion Criteria: * Having received any systemic treatment for psoriasis within the last 30 days * history of bleeding disorder * weight loss of 10 pounds in the last four weeks * current smoker * Known diagnosis of any unrelated autoimmune disease or inflammatory disease ( i.e. lupus, atopic dermatitis, rheumatoid arthritis). * Currently taking NSAIDS, aspirin, (if \> once a week, stopped \<30 days ago). Aspirin 81mg may be permitted if the Framingham Risk Score is \< 10 * Having received any anti-inflammatory medication within the last 30 days * Current use of any anti-coagulants * LFTs \> 2 x upper normal limits * HIV infection * Pregnant * Less than 6 weeks post partum * history of cardiovascular disease (MI, CHF, CVA) * Any cancer diagnosis within the last 5 years * Symptoms of acute illness such as upper respiratory infection, bronchitis, gastroenteritis, or fever within 3 days of Visit 1 * Any medical, psychological or social condition that, in the opinion of the Investigator, would jeopardize the health or well-being of the participant during any study procedures or the integrity of th…