CompletedNot Applicable

Hippocampal Metabolism and Function in Patients With Type 1 Diabetes

United States57 participantsStarted 2013-05

Plain-language summary

The hippocampus is an area of brain which plays an essential role in learning and memory processing and is thought to be particularly vulnerable to effects of hypoglycemia (low blood glucose). The goal of this project is to examine hippocampal neurochemistry and metabolism and identify how diabetes and recurrent hypoglycemia alter the hippocampus.

Who can participate

Age range20 Years – 70 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: diagnosis of type 1 diabetes, hemoglobin A1C \<9%. Alternatively, subject should be a healthy control. Exclusion Criteria: Exclusion criteria for both groups of subjects include history of stroke, seizures, neurosurgical procedures, or arrhythmias, and use of drugs that can alter glucose metabolism (other than insulin for the patients with diabetes). Subjects must also meet requirements for a study in the magnet, which includes weight less than 300 lbs. and the absence of metallic substances in their body.

What they're measuring

alterations in hippocampal glucose transport kinetics

Timeframe: data will be acquired at the time of experiment.

Trial details

NCT IDNCT01852968

SponsorUniversity of Minnesota

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2017-10-31

View on ClinicalTrials.gov More Hypoglycemia trials