A Study to Find the Minimum Inhibitory Concentration of KAE609 in Adult Male Patients With P. Falciparum Monoinfection

Key Inclusion Criteria: * Monoinfection with P. falciparum confirmed by microscopy * Asexual P. falciparum parasitemia count of 5,000 to 50,000/µL * Axillary temperature ≥37.5 ºC or oral/tympanic/rectal temperature ≥38 ºC; or similar documented temperature during the previous 24 hours * Body weight between 40 to 90 kg Key Exclusion Criteria: * Signs and symptoms of severe malaria according to World Health Organization (WHO) 2010 criteria * Mixed Plasmodium infection, i.e. infection with more than one species of malaria parasites * Use of other investigational drugs within 30 days or within 5 half-lives of enrollment, whichever is longer * History of antimalarial use within 2 months of screening * Use of any antibiotics with antimalarial activity or other prohibited medication within 14 days of screening * Long QT syndrome or QTc using Fridericia's formula \>430 msec * History of malignancy of any organ system (other than localized basal cell carcinoma of the skin), treated or untreated, within the past 5 years, regardless of whether there is evidence of local recurrence or metastases * Hemoglobin level \<10 g/dL * Liver disease or injury as indicated by elevated liver tests such as SGPT (ALT) or SGOT (AST) \>2 times the upper limit of normal * Renal dysfunction as indicated by serum creatinine \>2 times the upper limit of normal in the absence of dehydration; in case of dehydration, serum creatinine should be \<2 times the upper limit of normal after oral or parental rehyd…