A Prospective Study of Outcome After Therapy for Acromegaly

Acromegaly Subjects Inclusion Criteria: * Adult males and females. * Ages 18 and over. * Presenting to the PI or one of the sub-investigators for evaluation of acromegaly. * Must have a biochemical diagnosis of acromegaly consisting of an elevated serum insulin-like growth factor 1 (IGF-1) level. Supportive although not required for entry are an elevated growth hormone (GH) level and a failure of GH to suppress normally after oral glucose administration. * Willingness to participate in this study's procedures. Exclusion Criteria: * Subjects who are unwilling to comply with the procedures outlined in the study. * Subjects who do not have the ability to fully comprehend the nature of the study, to follow instructions, and/or cooperate with study procedures * Are unwilling to provide informed consent to participate in the study. Healthy Subjects Inclusion Criteria: * Adult males and females. * Ages 18 and over. * Responding to ads for participation or by word of mount. * No medical problems, no medications, stable weight for 3 months prior to study. * Willingness to participate in this study's procedures. Exclusion Criteria: * Subjects who are unwilling to comply with the procedures outlined in the study. * Subjects who do not have the ability to fully comprehend the nature of the study, to follow instructions, and/or cooperate with study procedures * Are unwilling to provide informed consent to participate in the study. * Failure to meet the inclusion criteria.