HPTN 073 Black Men Who Have Sex With Men (MSM) Pre-Exposure Prophylaxis (PrEP)

Inclusion Criteria: BMSM who meet all of the following criteria are eligible for inclusion in this study: * 18 years of age or older * No prior HIV diagnosis (self-report) * Male at birth * High risk for acquiring HIV infection including any one of the following in the previous 6 months: * Unprotected sex during receptive or insertive anal intercourse with a male partner * Any protected or unprotected: i. Receptive or insertive anal intercourse with more than three male sex partners ii. Exchange of money, gifts, shelter or drugs for receptive or insertive anal sex with a male partner iii. Receptive or insertive anal sex while under the influence of drugs or alcohol (i.e., high or drunk within two hours of the sex act) according to self-report" * STI diagnosis (i.e., syphilis, gonorrhea and chlamydia) by self-report * Willing to provide locator information in accordance with the Study Specific Procedures (SSP) Manual * Urine dipstick negative or trace for protein and glucose * Hemoglobin \> 11 g/dL, absolute neutrophil count \> 750 cells/mm3, and platelet count ≥ 100,000/mm3 * Serum creatinine \< upper limit of normal (ULN) and calculated creatinine clearance of at least 60 mL/min by the Cockcroft-Gault formula where: o eCcr in mL/min = \[(140 - age in years) x (actual body weight in kg)\] / (72 x serum creatinine in mg/dL) Alanine aminotransferase (AST) and aspartate aminotransferase (ALT) \< 3 times the upper limit of normal (ULN) * Total bilirubin \< 2.5 UL…