CompletedNot Applicable

Brain Response to Treatment for Pediatric PTSD

United States68 participantsStarted 2013-04

Plain-language summary

This study will examine how brain activation changes as a result of behavioral treatment for posttraumatic stress disorder (PTSD) in adolescents. The investigators will conduct functional magnetic resonance imaging (fMRI) scans before and after the widely-used trauma-focused cognitive behavioral therapy to better understand how the brain recovers from illness. This study will provide much needed information about brain abnormalities in abused youth, and could lead to improvements in behavioral treatments for patients who do not respond to current treatments.

Who can participate

Age range9 Years – 17 Years

SexALL

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Inclusion Criteria: * ages 12-17, history of physical or sexual abuse, witnessing violence, or bullying; and English speaking Exclusion Criteria: * receiving other psychotherapy currently, taking medications for a psychiatric disorder currently, history of head injury with loss of consciousness longer than 5 minutes; major medical condition such as epilepsy, diabetes, heart disease, or loss of hearing or vision, developmental disorder such as fragile X, autism, or Down's Syndrome, MRI contraindications including metal in the body from an injury or surgery, non-removeable piercings, or braces, Intelligence Quotient (IQ) \< 70; schizophrenia, bipolar disorder, current substance abuse.

What they're measuring

functional magnetic resonance imaging (brain activation)

Timeframe: change in brain activation after 4 months of treatment (baseline and 4 months)

Trial details

NCT IDNCT01806701

SponsorStanford University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-05

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