A New Minimal-invasive Brain Tissue Probe Applying Near Infrared Spectroscopy

Inclusion Criteria: * Males and females aged 18-75 years (inclusive) * Patients with high-grade subarachnoid hemorrhage (WFNS 4-5) * Decreased level of consciousness with the need for intracranial pressure monitoring * Successful exclusion of the ruptured aneurysm with clipping or coiling * Women of childbearing potential must have a negative serum pregnancy test * Written informed consent obtained by a legal representative Exclusion Criteria: * Significant kidney and/or liver disease * Any severe unstable concomitant condition or disease (e.g. cancer, coronary disease) or chronic condition (e.g. psychiatric disorder, chronic obstructive pulmonary disease Grade II, chronic heart failure \> NYHA II) * Cerebrospinal fluid infection or signs of meningoencephalitis * Acute respiratory distress syndrome (ARDS), pulmonary edema * Preexisting coagulation disorder * Patients with current alcohol or drug abusus or dependence * Patients with a history of hypersensitivity against indocyanine green or sodium iodine * Patients with thyroid disease causing hyperthyroidism * Breast-feeding women * Patients committed to an institution based on official directive or court order