CompletedNot Applicable

Carotid Artery Neovascularization in Takayasu's and Giant Cell Arteritis

United States7 participantsStarted 2010-08

Plain-language summary

The purpose of this study is to evaluate the ability of contrast enhanced carotid ultrasound to serve as an indicator of disease activity in patients with Takayasu's arteritis or Giant Cell arteritis and to determine if patients with active arteritis have a thickening of their blood vessel walls compared to healthy people of the same age and gender.

Who can participate

Age range18 Years – 100 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Male and female patients \>18 years * Diagnosis of Takayasu's arteritis or giant cell arteritis * Suspicion of common carotid involvement on the basis of physical examination (cervical bruit), carotidynia, documented CCA involvement on an imaging study (MRA, CTA, or ultrasound), or documented upper extremity large vessel involvement on an imaging study (MRA or CTA or ultrasound). * Ability to provide informed consent Exclusion Criteria: * Prior stroke, carotid surgery or angioplasty * Pregnant (or trying to become pregnant) * Nursing * Known or suspected cardiac shunt * Documented hypersensitivity to the contrast agent * Severe pulmonary hypertension or unstable cardiopulmonary conditions (acute myocardial infarction, acute coronary artery syndromes, worsening or unstable congestive heart failure, serious ventricular arrhythmias, or respiratory failure)

What they're measuring

Correlation between carotid IMT and neovascularization and disease activity

Timeframe: 3 days

Trial details

NCT IDNCT01795456

SponsorThe Cleveland Clinic

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2014-01

View on ClinicalTrials.gov More Takayasu's Arteritis trials