Efficacy Study of Intravenous Sodium Valproate in Addition to First Line Anti Epileptic Treatment of Generalized Convulsive Status Epilepticus.

Inclusion Criteria: * Patient older than 18. * Admitted in a participating ICU for generalized convulsive status epilepticus (GCSE) i.e. with persistent or repeated generalized seizures without regaining consciousness over a period of five minutes. provided that the duration of the treatment prior antiepileptic does not exceed: * Six hours if GCSE is already controlled at the time of inclusion (= disappearance seizures regardless of the state of consciousness) * Twenty-four hours if GCSE persisted or is recurrent. * Written informed consent collected from close relation or a family member of the patient. Otherwise, inclusion according to French Health Code in case of medical emergency. In this case, the written informed consent of patient has to be collected as soon as possible then. in absence of a close of patient, the patient may be still included. the consent of the prosecution will be collected Exclusion Criteria: * Other type of status epilepticus (including atypical form) occured before the onset of anti epileptic. * Female patient of childbearing age ≥ 18 ans et \< 50 ans * Patient prior treated by depakine in emergency for the GCSE * The length of stay in hospital expected before the occurrence of GCSE \> 15 days. * Expected Length of stay in ICU \<12h . * Hypoxic-ischemic encephalopathy. * Pregnant women, eclampsia checked by a systematic pregnancy test. * Pre-existing chronic or acute hepatitis, or Cirrhosis B or C. * Family history of acute hepatitis, espe…