CompletedEarly Phase 1

Mechanisms of Vasovagal Syncope

United States90 participantsStarted 2013-02

Plain-language summary

Vasovagal Syncope (simple postural faint) is the most common cause of acute loss of consciousness. Postural tachycardia syndrome(POTS) is the most common chronic form of postural lightheadedness. Together they afflict many Americans, mostly young women, who are prevented from gainful employ or school attendance. The underlying mechanism is not known. Our past work suggests that a simple molecule, nitric oxide, acts to subvert normal blood flow controls causing blood to pool in the gut when standing. Our proposal will show the mechanism behind this problem and will indicate effective medical treatments. Patients will be compared to healthy control subjects.

Who can participate

Age range14 Years – 29 Years

SexALL

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Inclusion criteria

✓. POTS patients referred for day to day orthostatic intolerance with greater than 3 symptoms for greater than 3 months and will have the diagnosis of symptomatic postural tachycardia made during a screening tilt table test :
✓. Vasovagal Syncope patients will have at least 3 episodes of fainting episodes in the past year.
✓. Healthy control subjects

What they're measuring

Heart rate and blood pressure in response to Lower Body Negative Pressure(LBNP)

Timeframe: 1 year

Trial details

NCT IDNCT01791816

SponsorNew York Medical College

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2022-12

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