Treatment for Presumed Ocular Histoplasmosis

Inclusion Criteria: * Active choroidal neovascularization (CNV) secondary to presumed ocular histoplasmosis demonstrated by active leakage on fluorescein angiography with spectal domain OCT evidence of subretinal or intraretinal fluid or PED. * Active CNV may also be defined as demonstrating active subretinal hemorrhage. * ETDRS Best corrected visual acuity 20/20-20/320. * willing and able to comply with all study clinic visits and study related procedures. * Willing to use and practice more than one form of contraceptives during the 13 month study for male and female. * Provide signed informed consent * Able to understand and complete study related questionnaires Exclusion Criteria: * Under 18 years of age * CNV due to other causes than Presumed Ocular Histoplasmosis * Previous treatment in the study eye within 6 months prior to Day 1 * More than 5 Intravitreal injections of anti-VEGF therapy within previous 12 months * Any clinical evidence of any other ocular condition other than Ocular histoplasmosis * History of allergy to fluorescein * Pregnant( or planning on becoming pregnant within the next 13 months) or breast feeding women * Sexually Active Men or Women who are NOT willing to practice more than one form of contraceptives during the next 13 months. * Anticipated or previous (within previous 3 months) systemic anti-VEGF therapy