Laser Intervention in Early Age-Related Macular Degeneration Study

Inclusion Criteria: * Males or females from 50 to 95 years of age at the time of consent * Best corrected visual acuity (BCVA) of 6/12 (20/40) or better in each eye. * Bilateral high-risk early AMD: At least one druse ≥125um within an inner macular zone (a circle with a radius of 1500 microns centred on the fovea) with or without pigment. * A MAIA static threshold sensitivity less than 25 dB at any point, within a customized grid, as measured using a Macular Integrity Assessment (MAIA) device), at the same location of the one eye on two separate occasions. * Pupil dilation of a least 5 mm in each eye * Fundus photographs, optical coherence tomography (OCT) and fundus autofluorescence (FAF) images of adequate quality as assessed by the LEAD Image Reading Centre. * Ability and willingness to consent, and be randomized, to the 2RT active or sham laser treatment, and all qualification and follow-up phases of the study. Exclusion Criteria: * Any evidence of definite geographic atrophy within the macula (a circle with a radius of 3000 microns centred on the fovea). * Any black (hypofluorescent) area of FAF consistent with GA (roughly round or oval shape, sharp margins), and corroborated on colour photography as a patch of hypopigmentation. * Any evidence of 'preclinical atrophy' as determined on OCT: loss of the outer retina (RPE and photoreceptors on the cube scan (Spectralis OCT) (49 horizontal B scans, 120 µm apart over a 20 x 20 degree scan). This covers approximately 6 x 6 …