CompletedNot Applicable

Second-line Therapy

Indonesia, Malaysia, Thailand300 participantsStarted 2011-01

Plain-language summary

This study will help identify which ARV candidates should be prioritized for pediatric use in resource-limited settings

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age \< 18 years old * Have confirmed HIV infection * Are being switched to or treated with second-line ART. Second-line ART is defined as the second regimen with a major antiretroviral class switch. For example, a switch from an NNRTI-based to a PI-based regimen or vice versa * Caregivers give informed consent. Children will be asked to give assent if they know their HIV status and have reached the minimum age to give assent according to each site's institutional review board regulations Exclusion Criteria: * Started mono- or dual- therapy as the first ART therapy * Failing first-line triple nucleoside reverse transcriptase inhibitor regimen * Are being switched to or treated with second-line ART without failure of first-line therapy (i.e., for toxicity) * Caregiver +/- child (if asked to give assent) refuses to participate in this study * Have not been enrolled in TApHOD

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

resistance

Timeframe: week 72

Trial details

NCT IDNCT01788891

SponsorThe HIV Netherlands Australia Thailand Research Collaboration

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2015-07

View on ClinicalTrials.gov More Treatment Failure of Second-line ART in Asian HIV-infected Children trials

Who can participate

Age range

18 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.