Efficacy and Safety of Sugammadex in Renal Diseased Patients

Inclusion Criteria: * age between 18 and 65 years old * end-stage renal disease defined by clearance of creatinine \< 30 ml/min * normal renal function defined by clearance if creatinine \> 90 ml/min * candidates to elective surgical procedures (control group) or kidney transplantation (renal group) under general anaesthesia Exclusion Criteria: * pregnant and breastfeeding women * patients with known or suspected neuromuscular disorders * patients with hepatic disfunction * a history of malignant hyperthermia * allergy to narcotics, rocuronium or other medication used during general anaesthesia * patients receiving medication known to interfere with the action of rocuronium (amino glycoside antibiotics, anticonvulsants, or magnesium)