Nicotine Treatment of Cognitive Decline in Down Syndrome

Inclusion Criteria: * Cognitive complaints and/or memory difficulties which are verified as new onset by an informant. * Cognitive Global Rating consistent with mild impairment or deterioration from premorbid baseline. * General cognition and functional performance sufficiently preserved such that a diagnosis of Alzheimer's disease/dementia cannot be made by the physician at the time of the screening visit. * No significant cerebrovascular disease: Modified Hachinski score of less than or equal to 4. * Age 25+. * Stable medications for at least 1 month prior to screening. Central nervous system (CNS) medications should be stable for 3 months. * No evidence of major depression. * Informant is available who has frequent contact with the subject (e.g. an average of 10 hours per week or more). * Adequate visual and auditory acuity to allow neuropsychological testing. * Good general health with no additional diseases expected to interfere with the study. * Normal B12, rapid plasma reagin (RPR), and Thyroid Function Tests or without any clinically significant abnormalities that would be expected to interfere with the study. * ECG without clinically significant abnormalities that would be expected to interfere with the study. * Subject is not pregnant, lactating. * Subjects will be taking no drugs with cholinergic properties (e.g donepezil). * Agreement not to take other vitamin or supplements other than multivitamins. * Negative urine pregnancy test in females. Exclusion Criteria…