In this investigation the investigators utilized NAC administration to foster GSH availability during an 8-day period following eccentric exercise-induced muscle damage in order to test our hypotheses: i) antioxidant supplementation does not disturb performance and adaptations induced by exercise-induced muscle injury and ii) redox status perturbations in skeletal muscle are pivotal for the regulation of muscle' inflammatory response and repair.
Age range
18 Years – 30 Years
Sex
MALE
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Change in reduced glutathione in blood
Timeframe: one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in reduced glutathione in muscle
Timeframe: one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise
Change in protein carbonyls in red blood cells and serum
Timeframe: one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in protein carbonyls in muscle
Timeframe: one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise
Change in thiobarbituric acid reactive substances in red blood cells and serum
Timeframe: one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in thiobarbituric acid reactive substances in muscle
Timeframe: one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise
Change in oxidized glutathione in red blood cells and blood
Timeframe: one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in total antioxidant capacity in serum
Timeframe: one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in oxidized glutathione in muscle
Timeframe: one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise
Change in catalase activity in red blood cells and serum
Timeframe: one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in glutathione peroxidase activity in red blood cells
Timeframe: one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in creatine kinase activity in plasma
Timeframe: one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in C-reactive protein in plasma
Timeframe: one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in macrophage infiltration in muscle
Timeframe: one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise
Change in white blood cell count in blood
Timeframe: one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in neutrophil count in blood
Timeframe: one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in fatty acid binding protein in plasma
Timeframe: one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in cortisol concentration in blood
Timeframe: one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in testosterone concentration in plasma
Timeframe: one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in cytokine concentration in plasma
Timeframe: one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in adhesion molecule concentration in blood
Timeframe: one hour before exercise, 5 minutes post-exercise, 2 hours post-exercise, daily for 8 days post-exercise
Change in intracellular signalling proteins in muscle
Timeframe: one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise
Change in myogenic determination factor (MyoD) protein levels in muscle
Timeframe: one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise
Change in tumor necrosis factor α in muscle
Timeframe: one hour before exercise, 2 hours post-exercise, 2 days post-exercise, 8 days post-exercise