Supraspinal Control of Lower Urinary Tract Function in Healthy Controls and Patients With Bladder Dysfunction

Inclusion Criteria: Healthy controls * Right handed * MR suitability * Written informed consent * unimpaired LUT function MS patients with OAB * Right handed * MR suitability * Written informed consent * diagnosis of MS according to the McDonald criteria * Expanded Disability Status Scale (EDSS) ≤ 6 * OAB symptoms since \> 6 months * ≥ 3 episodes of urinary urgency * frequency \> 8/24h * with or without detrusor overactivity MS patients without OAB * Right handed * MR suitability * Written informed consent * diagnosis of MS according to the McDonald criteria * Expanded Disability Status Scale (EDSS) ≤ 6 Patients with NNOAB * Right handed * MR suitability * Written informed consent * idiopathic OAB symptoms since \> 6 months * ≥ 3 episodes of urinary urgency * frequency \> 8/24h * refractory to antimuscarinic treatment for ≥ 1 month * indication for intradetrusor injections of Botulinumtoxin Type A * willingness and ability to perform self-catheterization SCI patients with neurogenic detrusor overactivity * Right handed * MR suitability * Written informed consent * neurogenic detrusor overactivity due to SCI * indication for intradetrusor injections of botulinum toxin type A Exclusion Criteria: Healthy controls * impaired LUT function * pregnancy or breast feeding * no informed consent * any craniocerebral injury or surgery * any permanent ferromagnetic implant * any previous surgery of the LUT or genitalia * any anatomical anomaly of the LUT or genitali…