CompletedNot Applicable

Supraspinal Control of Lower Urinary Tract Function in Healthy Controls and Patients With Bladder Dysfunction

Switzerland91 participantsStarted 2011-12

Plain-language summary

The purpose of this study is to provide profound insight into the supraspinal neuronal mechanisms and networks responsible for lower urinary tract (LUT) control and to verify, amend or adjust neuronal circuitry models established from findings in healthy subjects in the context of neurogenic and non-neurogenic LUT dysfunction.

Who can participate

Age range

18 Years – 55 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Healthy controls * Right handed * MR suitability * Written informed consent * unimpaired LUT function MS patients with OAB * Right handed * MR suitability * Written informed consent * diagnosis of MS according to the McDonald criteria * Expanded Disability Status Scale (EDSS) ≤ 6 * OAB symptoms since \> 6 months * ≥ 3 episodes of urinary urgency * frequency \> 8/24h * with or without detrusor overactivity MS patients without OAB * Right handed * MR suitability * Written informed consent * diagnosis of MS according to the McDonald criteria * Expanded Disability Status Scale (EDSS) ≤ 6 Patients with NNOAB * Right handed * MR suitability * Written informed consent * idiopathic OAB symptoms since \> 6 months * ≥ 3 episodes of urinary urgency * frequency \> 8/24h * refractory to antimuscarinic treatment for ≥ 1 month * indication for intradetrusor injections of Botulinumtoxin Type A * willingness and ability to perform self-catheterization SCI patients with neurogenic detrusor overactivity * Right handed * MR suitability * Written informed consent * neurogenic detrusor overactivity due to SCI * indication for intradetrusor injections of botulinum toxin type A Exclusion Criteria: Healthy controls * impaired LUT function * pregnancy or breast feeding * no informed consent * any craniocerebral injury or surgery * any permanent ferromagnetic implant * any previous surgery of the LUT or genitalia * any anatomical anomaly of the LUT or genitali…

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Bold signal

Timeframe: baseline and 4 weeks

Structural and functional connectivity

Timeframe: baseline and after potential OAB treatment

Trial details

NCT IDNCT01768910

SponsorUniversity of Zurich

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-07-17

View on ClinicalTrials.gov More Neurogenic Lower Urinary Tract Dysfunction trials