UnknownPhase 4

Algorithm Guided Treatment Strategies for Major Depressive Disorder

China1,080 participantsStarted 2012-06

Plain-language summary

The purpose of this study is to compare treatment outcomes between measurement based Algorithm Guided Treatment and Treatment As Usual strategies in a Chinese population with major depressive disorder.

Who can participate

Age range

18 Years – 75 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Meets Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) criteria for single or recurrent nonpsychotic major depressive disorder * Age 18-75 * Written informed consent completed * Scores 14 or higher on the 17-item Hamilton Depression Rating Scale * Initial treatment with escitalopram or mirtazapine or other antidepressants is clinically appropriate Exclusion Criteria: * History of bipolar disorder * Concurring psychotic disorders * Scores 3 or higher on item 3 (suicidal) of HRSD-17 * History of nonresponse to an adequate trial of escitalopram and/or mirtazapine * Has general medical condition, which contraindicates any leve 1 or 2 treatment option * Is on concomitant medication, which contraindicates any leve 1 or 2 treatment option * Any contraindication for mECT or rTMS * Is pregnant or breast feeding or is planning to get pregnant

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Remission defined as endpoint 17-item Hamilton Rating Scale for Depression (HRSD-17) total score ≤ 7

Timeframe: 12 weeks

Trial details

NCT IDNCT01764867

SponsorShanghai Mental Health Center

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2014-10

Contact for this trial

Zhiguo Wu, M.D.

862134289888 wu_zhiguo@yahoo.com.cn

View on ClinicalTrials.gov More Major Depressive Disorder trials

Who can participate

Age range

18 Years – 75 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.