CompletedNot Applicable

Influence of Preconceptional Obesity on the Myometrial Cells Differentiation Toward a Contractyl Phenotype

France38 participantsStarted 2012-04-06

Plain-language summary

The purpose of this study is to improve the understanding of cellular mecanism involved in delivery disorders in obese women, first by characterizing the hyperplasia phenomenon of myometrail cells induced by inflammatory stimulation (Il-1B), then by studying the role of blood mononuclear cells, of leptine and of obese women sera to interfere with the transition of myometrial cells toward hyperplasia phenotype.

Who can participate

Age range18 Years

SexFEMALE

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Inclusion Criteria: * Informed consent signed * Patient affiliated with a social security scheme * In front of for obstetrical reasons to give birth by caesarean section (scheduled caesarean section) * Or a woman who is not obese in labour and needs to undergo a cesarean section * No obvious infectious context * Age \> 18 years old Exclusion Criteria: * Obvious inflammatory or autoimmune diseases * Suspected or confirmed infectious context, including virale infection VIH, VHC, VHB * Coagulation disorders

What they're measuring

Measuring the expression level of markers (Gama actine, Desmine, Connexine-43, and Ocytocine receptor) by Westernblotting

Timeframe: up to 2 months

Trial details

NCT IDNCT01762683

SponsorCentre Hospitalier Universitaire Dijon

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2016-01-15

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