CompletedNot Applicable

Functional Connectivity in Primary Focal Dystonia

United States60 participantsStarted 2012-05

Plain-language summary

In this study we are looking at primary focal dystonias, including dystonias of the limbs, eyes, jaw or face, neck, and vocal chords. This study will use magnet resonance imaging (MRI) to see how the brain reacts while resting and doing a finger-tapping task. The investigators will test the hypothesis that disturbances in functional connectivity within the motor, affective and cognitive basal ganglia networks in primary focal dystonia (PFD) underlie the motor and non-motor symptoms in this disorder.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion Criteria: * English as their primary language * Volunteers with PFD and healthy controls * PFD volunteers must be on a stable dose of all dystonia and neuroactive drugs (e.g. antidepressants) for one month prior to enrollment * PFD volunteers must not have been injected with botulinum toxin within the prior 2 months Exclusion Criteria: * Any contraindication to MRI scanning * Any untreated neurological or psychiatric condition * Evidence on neurological exam of any potentially confounding neurological disorder (e.g., Parkinson disease, Essential Tremor, etc.) * Evidence of significant cognitive impairment (all subjects assessed using the Montreal Cognitive Assessment

What they're measuring

Contrast between Primary Focal Dystonia (PFD) and Healthy Controls (HC)

Timeframe: Day 1

Correlation between basal ganglia motor network functional connectivity measures and total PFD clinical assessment scale scores

Timeframe: Day 1

Trial details

NCT IDNCT01761903

SponsorUniversity of Colorado, Denver

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2018-06

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