Myocardial Inflammation in Systemic Lupus Erythematosus
United States40 participantsStarted 2012-07-01
Plain-language summary
The goal is to assess for myocardial edema on cardiac MRI during SLE flare to assess for myocardial inflammation.
Who can participate
Age range18 Years – 60 Years
SexALL
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Inclusion Criteria:
* • Diagnosis of SLE by American College of Rheumatology Classification Criteria \[21\]
* Active SLE Flare defined by Systemic Lupus Erythematosus Disease Activity Index (SLEDAI)\[22\] \> 6 or British Isles Lupus Assessment Group (BILAG) Index A or B.\[23\]
Exclusion Criteria:
* Pregnant
* Allergy to gadolinium
* Severe claustrophobia
* Renal replacement therapy or glomerular filtration rate (GFR) \< 30 mL/min/1.75m²
* Medically unstable for transportation to Ross MRI scanner. Stability will be defined as: not on mechanical ventilation, HR \< 120 BPM, MAP \> 65 mmHg. The treating providers' input on the patient's stability will also be considered in addition to these criteria
* Weight \> 500 pounds
* MR incompatible implanted devices such as neurostimulator pacemakers and implantable defibrillators, presence of intracranial metal or any metal not compatible with CMR