Reduced-Intensity Conditioning Before Donor Stem Cell Transplant in With High-Risk Hematologic Malignancies

Inclusion Criteria: * By definition, patients with hematological malignancies or dyscrasias that require HSCT as part of cure-directed therapy are by definition high-risk and can be treated on this protocol; examples of high risk patients include but are not limited to: * Acute myeloid leukemia with high risk features as defined by: * Age greater than or equal to 60 * Secondary acute myeloid leukemia (AML) (prior therapy or hematologic malignancy) * Normal cytogenetics but fms-related tyrosine kinase 3 (FLT3)/internal tandem duplication (ITD) positive * Any relapse or primary refractory disease * Greater than 3 cytogenetic abnormalities or any one of the following cytogenetic abnormalities: -5/del(5q), -7/del(7q), Abn(9q), (11q), (3q), (21q), (17p), t(6;9), t(6;11), t(11;19), +8, del(12p), inv(3), t(10;11), -17, 11q 23 * Any single autosomal monosomy * Acute lymphoid leukemia in 1st or 2nd morphological remission; ALL with any morphological evidence of disease will not be eligible * Myelodysplasia (MDS) other than refractory anemia (RA), refractory anemia with rare sideroblasts (RARS), or isolated 5q- syndrome subtypes * Hodgkin's or Non-Hodgkin's lymphoma in 2nd or greater remission or with persistent disease * Myeloma with evidence of persistent disease after front-line therapy * Chronic myeloid leukemia (CML) resistant to signal transducer inhibitor (STI) therapy * Myelofibrosis and chronic myelomonocytic leukemia (CMML) * Essenti…