Correlation Between Clinical and Electrophysiological Phenotypes in a Population of Patients With… (NCT01750710) | Clinical Trial Compass
CompletedNot Applicable
Correlation Between Clinical and Electrophysiological Phenotypes in a Population of Patients With Neuropathy Charcot-Marie-Tooth Disease Type 1A
France37 participantsStarted 2012-12
Plain-language summary
This exploratory cross-sectional study proposes, firstly, to objectify in a population of Charcot-Marie-Tooth disease type 1A (CMT 1A)if there is a correlation between the recording of electrical parameters and upper limb muscle strength of the thigh and in a second step, to seek a relationship between the measured parameters.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* Patients older than 18 years
* Diagnosis of Charcot Marie Tooth disease, type 1A confirmed by molecular biology (duplication 17.p11.2)
* Listening and written French
* Agreement after written information, clear and honest about the purpose of the study, the nature of the tests and their possible side effects or bothersome.
* Strength of the quadriceps superior to 2/5 MMT MRC
Exclusion Criteria:
* Presence of other neurological comorbidity
* Presence of coronary artery disease unstabilized
* Peripheral neuropathy of other causes: diabetes, monoclonal gammopathy, malignancy, solid cancer, systemic autoimmune disease (lupus, Sjögren's disease, Wegener sarcoidosis ...), infectious disease (viral hepatitis, HIV ...), drugs known to be responsible for iatrogenic neuropathy.
* Gait trouble of other origin
* Patients unable to give their consent.
* Intellectual deficit that does not allow to comply with tests