CompletedNot Applicable

Vitamin E Level in Buccal Cells of Arsenicosis Patients

Bangladesh60 participantsStarted 2010-10

Plain-language summary

To understand the pathogenesis of chronic arsenic toxicity, the investigators need to know the levels of vitamin E in patients chronically exposed to high concentration of arsenic and if changes are found, what happens when supplemented with vitamin E. The buccal cells and serum of patients will be collected for the estimation of vitamin E both before and after supplementation with vitamin E. Similar samples will be collected from similar number of arsenic exposed controls and healthy volunteers for comparison.

Who can participate

Age range18 Years – 70 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: For arsenicosis * who drank arsenic contaminated water (\>50 µg/L) for more than 6 months * having physical signs of moderate degree of melanosis and keratosis For arsenic exposed control * relative or family member of the patient * showing no physical signs of melanosis and keratosis * share same tube well water for drinking purpose for more than 6 months For healthy volunteers * who drank arsenic safe water (\<50 µg/L) * live in the same Upazilla * have no cutaneous manifestation * who voluntarily agree to participate Exclusion Criteria: * tuberculosis, eczema psoriasis, contact dermatitis * patients getting treatment of arsenicosis * subject who voluntarily do not agree to participate

What they're measuring

Change in the amount of vitamin E in buccal cells

Timeframe: 0 week (baseline), 20 weeks (end)

Trial details

NCT IDNCT01743066

SponsorBangabandhu Sheikh Mujib Medical University, Dhaka, Bangladesh

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2011-06

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