CompletedNot Applicable

Complete vs Culprit-only Revascularization to Treat Multi-vessel Disease After Early PCI for STEMI

Canada4,042 participantsStarted 2013-02-01

Plain-language summary

To determine whether, on a background of optimal medical therapy, including ticagrelor, opening of all suitable narrowings or blockages found at the time of primary PCI for an acute heart attack is better than treating only the culprit lesion in patients with multi-vessel disease.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Men and women within 72 hours after successful PCI (preferably using a drug eluting stent) to the culprit lesion for STEMI. PCI for STEMI can be either primary PCI or rescue PCI for failed fibrinolysis or a combination strategy where PCI is performed routinely 3-12 hours after fibrinolysis AND
✓. Multi-vessel disease defined as at least 1 additional non-infarct related coronary artery lesion that is at least 2.5 mm in diameter that has not been stented as part of the primary PCI and that is amenable to successful treatment with PCI and has:

Exclusion criteria

✕. Planned revascularization of non-culprit lesion
✕. Planned surgical revascularization
✕. Non-cardiovascular co-morbidity reducing life expectancy to \< 5 years
✕. Any factor precluding 5 year follow-up
✕. Prior Coronary Artery Bypass Graft (CABG) Surgery

What they're measuring

Composite of Cardiovascular death or new myocardial Infarction

Timeframe: over duration of follow-up (average of approximately 4 years)

Composite of cardiovascular death, new myocardial infarction or ischemia-driven revascularization

Timeframe: over duration of follow-up (average of approximately 4 years)

Trial details

NCT IDNCT01740479

SponsorPopulation Health Research Institute

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2019-06-07

View on ClinicalTrials.gov More Acute Myocardial Infarction trials

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Men and women within 72 hours after successful PCI (preferably using a drug eluting stent) to the culprit lesion for STEMI. PCI for STEMI can be either primary PCI or rescue PCI for failed fibrinolysis or a combination strategy where PCI is performed routinely 3-12 hours after fibrinolysis AND
✓. Multi-vessel disease defined as at least 1 additional non-infarct related coronary artery lesion that is at least 2.5 mm in diameter that has not been stented as part of the primary PCI and that is amenable to successful treatment with PCI and has:

Exclusion criteria

✕. Planned revascularization of non-culprit lesion
✕. Planned surgical revascularization
✕. Non-cardiovascular co-morbidity reducing life expectancy to \< 5 years
✕. Any factor precluding 5 year follow-up
✕. Prior Coronary Artery Bypass Graft (CABG) Surgery

What they're measuring

Composite of Cardiovascular death or new myocardial Infarction

Timeframe: over duration of follow-up (average of approximately 4 years)

Composite of cardiovascular death, new myocardial infarction or ischemia-driven revascularization

Timeframe: over duration of follow-up (average of approximately 4 years)