Magnetic Resonance Imaging Screening in Li Fraumeni Syndrome

Inclusion Criteria: * Carrier of germline TP53 mutation which, in the view of the geneticist, is not known to be low penetrance OR non-related individual with no personal history of malignancy and no first degree relatives diagnosed with malignancy under the age of 50 years * Please note, TP53 carrier cohort is complete and no longer open to recruitment * Age between 18 and 60 * Able to give informed consent Exclusion Criteria: * Individual with low penetrance TP53 mutation * Individual with TP53 variant of unknown significance. * Previous malignancy diagnosed \< 5 years ago in TP53 carriers (except non-melanomatous skin cancer or cervical CIS) Previous history of malignancy in non-related controls (except non-melanomatous skin cancer or cervical CIS) * Current symptoms suggestive of malignancy * Contraindication to MRI (such as non-MR compatible metal implants) as specified by the standard MR safety checklist * Claustrophobia * ECOG performance status \>2