CompletedNot Applicable

A Study of the Effect of Arterial Carbon Dioxide Tension on the Recovery of Spontaneous Respiration

United States50 participantsStarted 2012-09

Plain-language summary

The investigators data reveal an important new observation regarding the recovery of breathing during emergence from general anesthesia: respiration resumes as a prolonged abdominal expiration event. The present study aims to further clarify the physiology of recovery of breathing with the addition of a cutaneous monitor for arterial carbon dioxide measurement and a comparison of two different recovery paradigms.

Who can participate

Age range18 Years – 80 Years

SexALL

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Inclusion criteria

✓. Male or Female patients ages \> 18 to \< 80
✓. Scheduled for procedures under general anesthesia with jet ventilation
✓. Sign informed consent
✓. Candidate for total intravenous anesthesia with propofol and remifentanil (which is standard protocol in this type of population)

Exclusion criteria

✕. Absence of informed consent
✕. No planned use intra-operative use of jet ventilation
✕. Known difficulties with jet ventilation during prior surgical procedures
✕. Emergency surgery
✕. Baseline (oxygen saturation)SpO2 \<92% on room air
✕. BMI \> 50
✕. Pregnant or lactating females
✕. Skin damage, rash or significant lesions in the areas covered by the RIP bands or transcutaneous CO2 sensor.

What they're measuring

spontaneous breathing

Timeframe: Day 0 in the operating room occurring in the specific time frame of the end of anesthesia to patient 's first breath

Trial details

NCT IDNCT01733446

SponsorUniversity of Pennsylvania

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2018-02

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