UnknownPhase 1

Autologous Bone Marrow Mesenchymal Stem Cell Transplantation for Chronic Stroke

China30 participantsStarted 2012-06

Plain-language summary

Stroke is one of the leading causes of disability in the world, and stem cell - transplantation provides a promising approach for rehabilitation. The main objective of this study is to evaluate the efficacy of the intracerebral injection of autologous bone marrow mesenchymal stem cells in patients with chronic stroke.

Who can participate

Age range

40 Years – 70 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Aged 40-70 ischemia stroke or intracerebral hemorrhage patient * With stroke history of more than 3 months, less than 60 months * With stable hemiplegia condition * NIHSS (NIH stroke scale) score of 7 or more points * Patient is stable (normal respiration, afebrile, BP less than mean arterial pressure of 125 mm of Hg, fasting blood sugar \<7 mg, and normal urea/electrolytes for at least 48 hours.) Exclusion Criteria: * Patients aged less than 40 or more than 70 * Lacunar infarction * History of neurological disease, head injury or psychiatric disorder with disablity * Pregnant women * Impaired liver function, abnormal blood coagulation, AIDS, HIV, combine other tumor or special condition * Inaccessibility for follow up * Unwillingness to provide written informed consent

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change from baseline in NIH Stroke Scale at 12 months

Timeframe: 1, 6 and 12 months

Trial details

NCT IDNCT01714167

SponsorWenzhou Medical University

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-10

Contact for this trial

Qichuan Zhuge, M.D.

zhugeqichuan@vip.163.com

View on ClinicalTrials.gov More Stroke trials