Reservoir-Based Polymer-Free Amphilimus-Eluting Stent Versus Polymer-Based Everolimus-Eluting Stent in Diabetic Patients

Clinical Inclusion Criteria: * Subject is eligible for PCI. * Subject has symptomatic coronary artery disease (stable/unstable angina or Non-ST elevation myocardial infarction). * Subject has known DM. Angiographic Inclusion Criteria: * Presence of 1 or 2 de novo native coronary artery lesions (maximum 1 lesion per epicardial coronary artery), with a visual estimation stenosis ≥ 50%. * Target lesion length 12-25mm, reference diameter 2.5-3.5mm. Clinical Exclusion Criteria: * ST-segment elevation myocardial infarction \<48h * Presence of cardiogenic shock pre-procedure * Contra-indications to dual antiplatelet therapy for 12 months * Left Ventricular Ejection Fraction ≤30% * GFR\<30 ml/min/m2 * Target vessel has been treated previously * Platelet count \<75000/mm3 or \>700000/mm3 * Immunosuppressive therapy * Has received or waiting list for any transplant * Life-threatening disease with a life expectancy of \< 12 months * Pregnant or breast feeding patient * Inability to provide informed consent Angiographic Exclusion Criteria: * TIMI flow ≤ 1 prior to guide wire crossing * There is an additional lesion within the target vessel planned to be treated within the next 12 months * Target vessel is a saphenous vein graft * Target vessel is the left main, ostial LAD and/or ostial LCX. * Prior PCI of the target lesion (restenosis) * Lesion cannot be covered by a single stent (unplanned bailout stenting is allowed) * Involved side branch ≥2.5mm by visual estimation * Rotablato…