CompletedNot Applicable

Peritoneal Dialysis vs Furosemide for Acute Kidney Injury After Cardiopulmonary Bypass

United States73 participantsStarted 2011-10

Plain-language summary

Acute kidney injury (AKI) after cardiopulmonary bypass (CPB) in infants is common and associated with poor outcomes. Peritoneal dialysis (PD) and furosemide have been used to attain negative fluid balance due to AKI induced oliguria, but have not been compared prospectively. The investigators will prospectively compare outcomes of infants with oliguria after CPB randomized to PD vs. furosemide with the hypothesis that infants receiving PD have superior outcomes.

Who can participate

Age range6 Months

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age less than 6 months of age; * Undergoing cardiothoracic surgery with CPB; * Planned placement of PD catheter per institutional standard of care criteria. Exclusion Criteria: * Pre-existing chronic kidney disease stage 3 or above (correlating with estimated GFR\<60 ml/min/m2, which will be calculated using routine preoperative serum creatinine value using the modified Schwartz equation). * Known history of allergy to furosemide.

What they're measuring

Number of Participants With Negative Fluid Balance on Postop Day 1

Timeframe: Postop day 1

Trial details

NCT IDNCT01709227

SponsorChildren's Hospital Medical Center, Cincinnati

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-06

Results submitted2017-01-31

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