CompletedNot Applicable

Nicotinic Receptor Levels After Stopping Smoking

United States20 participantsStarted 2010-10

Plain-language summary

This positron emission tomography (PET) study examines the effects of 24 hours abstinence from smoking on return to availability of neuronal nicotinic receptors in slow and fast metabolizers of nicotine.

Who can participate

Age range

18 Years – 65 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Ages 18 to 65 years old.
. Smoke 10 cigarettes per day for the previous 6 months.
. Weigh less than 300lbs (due to limitations of the PET and MRI scanners).

Exclusion criteria

. Smoking behavior:
. Current enrollment or plans to enroll in a smoking cessation program, or use other smoking cessation medications in the next 2 months.
. Provide a CO reading of less than 10 ppm at medical screening.
. Alcohol/Drugs:
. History of substance abuse and/or currently receiving treatment for substance abuse (e.g., alcohol, opioids, cocaine, marijuana, or stimulants).
. Positive drug screen at any of the sessions (see page 8 for list of drugs and/or contra-indicated medications).
. Current alcohol consumption that exceeds 25 standard drinks/week.
. Providing a breath alcohol concentration (BrAC) reading of greater than or equal to 0.01 at any session.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in α4β2* nAChR binding potential

Timeframe: Week 1 and up to Week 5

Trial details

NCT IDNCT01704573

SponsorUniversity of Pennsylvania

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2012-03

View on ClinicalTrials.gov More Nicotine Addiction trials