CompletedNot Applicable

Nicotinic Receptor Levels After Stopping Smoking

United States20 participantsStarted 2010-10

Plain-language summary

This positron emission tomography (PET) study examines the effects of 24 hours abstinence from smoking on return to availability of neuronal nicotinic receptors in slow and fast metabolizers of nicotine.

Who can participate

Age range18 Years – 65 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

✓. Ages 18 to 65 years old.
✓. Smoke 10 cigarettes per day for the previous 6 months.
✓. Weigh less than 300lbs (due to limitations of the PET and MRI scanners).

Exclusion criteria

✕. Smoking behavior:
✕. Current enrollment or plans to enroll in a smoking cessation program, or use other smoking cessation medications in the next 2 months.
✕. Provide a CO reading of less than 10 ppm at medical screening.
✕. Alcohol/Drugs:
✕. History of substance abuse and/or currently receiving treatment for substance abuse (e.g., alcohol, opioids, cocaine, marijuana, or stimulants).
✕. Positive drug screen at any of the sessions (see page 8 for list of drugs and/or contra-indicated medications).
✕. Current alcohol consumption that exceeds 25 standard drinks/week.
✕. Providing a breath alcohol concentration (BrAC) reading of greater than or equal to 0.01 at any session.

What they're measuring

Change in α4β2* nAChR binding potential

Timeframe: Week 1 and up to Week 5

Trial details

NCT IDNCT01704573

SponsorUniversity of Pennsylvania

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2012-03

View on ClinicalTrials.gov More Nicotine Addiction trials