CompletedNot Applicable

Change in Airway Responsiveness After Allergen Exposure

Canada11 participantsStarted 2012-10

Plain-language summary

Exposure to allergens changes the way the airway responds to some stimuli (methacholine). The investigators will look at whether or not exposure to allergens changes the way the airway responds to a different stimuli (mannitol) and compare that with the known stimuli (methacholine).

Who can participate

Age range18 Years – 65 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * mild, allergic asthma * FEV1 greater than 70% predicted * methacholine PC20 less than or equal to 16mg/ml Exclusion Criteria: * known sensitivity to mannitol or other excipient * diagnosis of any other respiratory or non respiratory disease/disorder that would preclude the individual from participating * recent thoracic, abdominal or eye surgery * recent allergen exposure (4 weeks), respiratory infection (6 weeks) * current immunotherapy * pregnancy * history of anaphylaxis * use of asthma therapies other than short acting beta agonist

What they're measuring

Change from baseline in airway responsiveness three hours after allergen exposure

Timeframe: Change from Baseline at 3 hours

Trial details

NCT IDNCT01699594

SponsorUniversity of Saskatchewan

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2014-05

View on ClinicalTrials.gov More Allergic Asthma trials