Prevention of Bladder Dysfunction in Acute Spinal Cord Injury

Inclusion Criteria: * Patients with documented acute, motor complete C6 to Th11 spinal cord injury * Patients can be included in the study less than four weeks after injury * Male or female, aged 18 to 80 years old * Patient weight \> 40 kg * Patient is able and willing to sign informed consent * Patient is able to complete all study requirements Exclusion Criteria: * Neurogenic detrusor overactivity with contractions greater than 40 cm H2O at first visit * History or evidence of previous urological abnormalities, disease or surgery, except bladder dysfunction after spinal cord injury * History of haematuria or ongoing haematuria, if the hematuria is determined to be a pathologic condition or is uninvestigated * Pregnancy or females of childbearing potential unwilling to use a reliable form of contraception * Breastfeeding * Known allergy to Onabotulinumtoxin A * Grave psychiatric disorder * Use of anti-platelet or anti-coagulant other than low molecular weight heparin (LMWH) or acetylsalicylic acid * Haemophilia or other clotting disorders that cause bleeding diathesis * Treatment with antimuscarinic medication within 3 months of randomization * Treatment with botulinum toxin of any serotype within 3 months of randomization * Patient has been immunized for any botulinum toxin serotype * Patient has any medical condition that may put the patient at increased risk with exposure to botulinum toxin including diagnosed myasthenia gravis, Eaton-Lambert syndrome or amyotrophic l…