TerminatedNot Applicable

The Role of Uterine NK Cells and T Cell Cytokines in Recurrent Miscarriage

Egypt500 participantsStarted 2010-03

Plain-language summary

The aim of the study is to evaluate the role of uterine natural killer cell(uNK)in recurrent pregnancy losses and the correlation between the numbers of it and embryo toxicity by measuring the level of the Th2 cytokines in normal reproductive profile and in patients with Recurrent Pregnancy Losses (RPL).

Who can participate

Age range18 Years – 40 Years

SexFEMALE

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Inclusion criteria

✓. Women with unexplained recurrent miscarriages (2 or more consecutive).
✓. All patients have normal uterine cavity diagnosed by HSG and /or hysteroscopy, normal semen analysis, normal thrombophilic profiles, no history of malformed
✓. normal fetus in the previous miscarriages

Exclusion criteria

✕. Age above forty years old .
✕. Antiphospholipid syndrome (lupus anticoagulant and/or anticardiolipin antibodies \[IgG or IgM\]); other recognised thrombophilic conditions (testing according to usual clinic practice).
✕. Intrauterine abnormalities (as assessed by ultrasound, hysterosonography, hysterosalpingogram, or hysteroscopy).
✕. Fibroids distorting uterine cavity .
✕. Abnormal parental karyotype .
✕. Other identifiable causes of recurrent miscarriages (tests initiated only if clinically indicated) e.g., diabetes, thyroid disease and systemic lupus erythematosus (SLE).

What they're measuring

the role of uterine natural killer cell(uNK)in recurrent pregnancy losses and the correlation between the numbers of it and embryo toxicity by measuring the level of the Th2 cytokines in normal reproductive profile and in patients with RPL.

Timeframe: two years

Trial details

NCT IDNCT01688284

SponsorWoman's Health University Hospital, Egypt

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2012-08

View on ClinicalTrials.gov More Recurrent Pregnancy Losses trials