UnknownPhase 3

Sputum Cytometry Analysis in Lung Cancer Screening After Professional Asbestos Exposure

France1,000 participantsStarted 2012-09

Plain-language summary

Workers exposed to asbestos are at high risk of lung cancer. Medical follow-up of this population relies on repeated CT-scans which are more accurate for detection of peripheral lesions, and expose to X-rays and to risk of false-positives. Analysis of sputum using automate cytometry may be of interest in this population, alone or in combination with CT-scan. An ancillary study will evaluate the interest of blood predictive biomarkers.

Who can participate

Age range56 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * High professional asbestos exposure * Member of a former cohort recruited between 2000 and 2006 in Caen, Rouen and Le Havre (inclusion criteria: 50-75 years at the time of initial recruitment, high intermittent asbestos exposure \>= 1 year, or high discontinuous asbestos exposure \>=10 years). All the living members of the cohort will be contacted: a maximum of 1000 subjects is expected, probably less. * Informed consent signed Exclusion Criteria: * Personal history of lung cancer * Refusal of the study protocol * Uncontrolled asthma or lung failure

What they're measuring

Risk of false positive

Timeframe: within 3 months

detection of lung cancer

Timeframe: within 3 months

Trial details

NCT IDNCT01687647

SponsorUniversity Hospital, Caen

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2015-03

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