UnknownEarly Phase 1

Exercise Capacity and Quality of Life in Patients With PPH Receiving Short Term Oral L-Citrulline Malate

Iran25 participantsStarted 2012-08

Plain-language summary

Due to vasodilatory properties of the NO, one of the therapeutic approaches for IPAH is oral use of nitric oxide precursors (10). Efficacy of L-arginine is well-documented in the current literature but there is paucity of data with regard to L-citrulline- malate. Hence, this study will evaluate therapeutic efficacy of L-citrulline- malate in two categories of patients with pulmonary hypertension (IPAH, and Eisenmeger syndrome). This randomized clinical trial utilizes 6-minute walk, pro BNP levels and the echocardiographic indexes an indicator of functional improvement of the patients.

Who can participate

Age range15 Years – 70 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * all patients less than 70 years old, * patients with a six-minute walking distance of more than 100 meters (m), * a mean pulmonary arterial pressure (PAP) ≥ 25 mmHg at rest as assessed by right heart catheterization(RHC) (11,12). Exclusion Criteria: * all patients more than 70 years old, * patients with a six-minute walking distance of less than 100 meters (m), active pulmonary or extra pulmonary infection, * serious coronaropathy and/ or ventricular dysfunction, * significant renal illness and/or hepatitis, * detected immunosuppressive illnesses, * carrier of known neoplasias, * pregnancy, * lack of family support, * psychosocial problems, * drug or alcohol abuse, and * noncompliance with established medical protocol.

What they're measuring

the change in exercise capacity

Timeframe: 2 weeks

Trial details

NCT IDNCT01683981

SponsorMasih Daneshvari Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2013-08

Contact for this trial

babak sharif kashani, Cardiologist

0098-02188883114 sharifk@nritld.ac.ir