Effect of Botulinum Toxin A on Detrusor Overactivity and Renal Function in Chronic Spinal Cord Injured Patients

Inclusion Criteria: * Adults with age of 19 years old or above * Patients with chronic suprasacral cord SCI will be enrolled. * Patients will be proven having NDO by videourodynamic study during the screening period. * They also receive 99mTc-DTPA renal scanning for GFR at baseline. * Patients with NDO induced urinary incontinence who have adequate hand function or have a care-giver available for CIC, and the baseline total GFR of less than 80 mL/min are main inclusion criteria Exclusion Criteria: * Patients with detrusor underactivity and large bladder compliance, patients proven to have intrinsic sphincteric deficiency * Patients who have hypersensitivity to BTX-A or constituent ingredients of BTX-A.